Zelnorm

Zelnorm (also Zelmac) is the brand name for the pharmaceutical product Tegaserod, marketed by Novartis as a remedy for irritable bowel syndrome (IBS) and constipation. Zelnorm was introduced to the U.S. market in 2002, subsequent to Food and Drug Administration (FDA) approval.

In 2007, the FDA asked Novartis to take Zelnorm off the market, based on an analysis of data by the agency. After receiving reports that Zelnorm might be tied to increased risk of stroke or heart attack, the FDA reviewed data from more than 18,000 patients. The study showed that the incidences of cardiovascular problems of people who took Zelnorm was more than 10 times the rate of those who took a placebo.

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